Hydrogen sulfide: a new EDRF

Hydrogen sulfide: a new regulator of osteoclastogenesis?

Blood pressure control: hydrogen sulfide, a new gasotransmitter, takes stage.

Hydrogen sulfide (H2S) is the most recently characterized autocrine/paracrine messenger implicated in the control of vascular tone. A series of coherent observations now document that this gas is a strong vasorelaxant and a determinant of blood pressure in experimental models. Targeted deletion of the gene encoding cystathionine-lyase (CSE). CSE, a key enzyme for H2S biosynthesis, reduces serum...

Predicting Hydrogen Sulfide Formation in Sewers: a New Model

A new model has been developed both as a research tool and in collaboration with industry partners. In this paper, the successful application of the model to simulate rising main systems on the Gold Coast was demonstrated and tested in systems with oxygen injection intended for control of dissolved sulfide and odour.

Hydrogen sulfide prodrugs—a review

Hydrogen sulfide (H2S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO). As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the development of H2S prodrugs for various reasons. In this review, we summarize different H2S prodrugs, t...

Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.

BACKGROUND The potential biological significance of hydrogen sulfide (H(2)S) has attracted growing interest in recent years. The aim of this study was to characterize a novel, water-soluble, slow-releasing H(2)S compound [morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137)] and evaluate its use as a tool to investigate the cardiovascular biology of this gas. METHODS AND R...